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FlashFREEZE

Standardized and documented pre-analytical protocols for enhanced tissue banking procedures

FlashFREEZE

The science of flash freezing for standardized tissue banking

WHAT SETS FlashFREEZE APART ?

The unique combination of a non-toxic heat transfer fluid with a state-of-the-art Stirling cooling device at -80°C allows standardized and documented flash freezing protocols.


The problem

Start with a good preparation

Human biospecimens have been collected and stored for over 100 years, and today, more than of 300 million biospecimens are warehoused in freezers or stored in other formats such as paraffin-embedded tissue blocks1. However, over the past decade or so it has become clear that the great majority of biospecimens stored in the world’s biorepositories may not be suited for the state-of-the-art genomics, proteomics, metabolomics, and other bioanalytical technologies used today to search for cancer-related biomarkers. The irreproducibility of many reported biomarkers is due at least in part to the fact that the biospecimens utilized are often procured using different collection, processing and storage techniques2.
Such variability can lead to significant differences in the biospecimen’s molecular integrity.

1 Eiseman E, Haga S. A Handbook of Human Tissue Sources. Santa Monica, CA: RAND Corporation; 2000
2 International Approaches to Advancing Biospecimen Science. Helen M. More et all. Cancer Epidemiol Biomarkers Prev. May 2011; 20(5): 729-732

The solution

The solution

To overcome some of these difficulties, Milestone has developed the FlashFREEZE unit to standardize the flash freezing processing step of biospecimens. With FlashFREEZE, it is now possible to carry out evidence-based freezing protocols on biospecimens with the full documentation needed for QA purposes.

THIS IS HOW FLASH FREEZING SHOULD BE

  • High flexibility: Flash freeze vials with a volume of up to 50ml. Suitable for freezing 24/48/96 well plates or random biospecimens
  • High safety standards: No liquid nitrogen, no isopentane. Histology grade ethanol is used as a heat transfer fluid and is suitable for non-contact freezingprocedures of biospecimens or fluids
  • Full automation: programmable freezing temperatures down to -80°C; Programmable length of the freezing step.
  • Fully documentable: software upgrading and download of event logs through the USB port

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Simple and intuitive operations make everyone an expert


FLASH FREEZING OF RANDOM CRYOVIALS

FLASH FREEZING OF RANDOM CRYOVIALS

Thanks to the completely new Freezing box, the FlashFREEZE can accommodate the random sieve-type holder, allowing to freeze:
1. Up to 25 cryovials simultaneously
2. Vials with a volume up to 50 ml.
FLASH FREEZING OF MICROTITER PLATES

FLASH FREEZING OF MICROTITER PLATES

The flash freezing of microtiter plates is now possible.
The rack holder accepts 24/48/96-well plates.
FREEZING OF CRYOMOLDS

FREEZING OF CRYOMOLDS

The cryomold kit offers the unique application capability of freezing samples in plastic cryomould. Up to three samples can be frozen simultaneously. The fluid inside the set level tank freezes only the mold without contaminating the specimen.

Video

Watch our video to discover our product in action! Unique design, outstanding quality and technology innovation are key features.

Catalog

Take a moment to consult our catalog to learn all the advantages of Milestone cutting-edge FlashFREEZE unit.

FlashFREEZE
Milestone Biobanking Processing

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PRESTO

PRESTO
Automating and programming the staining protocols.
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